Effect of lipoic acid consumption on oxidative stress among multiple sclerosis patients: A randomized controlled clinical trial

Abstract

Objectives

Multiple sclerosis is a neurodegenerative and demyelinating disease of central nervous system. High levels of oxidative stress are associated with inflammation and play an important role in pathogenesis of multiple sclerosis. This double-blind, randomized controlled clinical study was carried out to determine the effect of daily consumption of lipoic acid on oxidative stress among multiple sclerosis patients.

Methods

A total of 52 relapsing-remitting multiple sclerosis patients, aged 18–50 years with Expanded Disability Status Scale ≤5.5 were assigned to consume either lipoic acid (1200 mg/day) or placebo capsules for 12 weeks. Fasting blood samples were collected before the first dose taken and 12 hours after the last. Dietary intakes were obtained by using 3-day dietary records.

Results

Consumption of lipoic acid resulted in a significant improvement of total antioxidant capacity (TAC) in comparison to the placebo group (P = 0.004). Although a significant change of TAC (−1511 mmol/L, P = 0.001) was found within lipoic acid group, other markers of oxidative stress including superoxide dismutase activity, glutathione peroxidase activity, and malondialdehyde levels were not affected by lipoic acid consumption.

Discussion

These results suggest that 1200 mg of lipoic acid improves serum TAC among multiple sclerosis patients but does not affect other markers of oxidative stress.

Keywords:

• Multiple sclerosis
• Lipoic acid
• Oxidative stress
• Reactive oxygen species
• Total antioxidant capacity
• Malondialdehyde
• Superoxide dismutase
• Glutathione peroxidase

Acknowledgment

This study was supported by a grant (No. 948) from the Vice-Chancellor for Research, Tehran University of Medical Sciences, Iran. The authors would like to thank patients who participated in this study.