Temporal changes of adiponectin plasma levels in patients with acute ischemic stroke

Abstract

Adiponectin, an adipocyte-derived hormone, possesses anti-inflammatory properties. Its decreased levels were noted in patients with ischemic stroke (IS). Animal studies suggest that the decline of adiponectin levels in the acute IS phase is a dynamic process. The aim of the present study was to analyze the temporal expression of the adiponectin plasma levels in patients with acute IS. Thirty-one consecutive patients with first-ever IS (mean age±SD: 69·5±12·5 years; 12 women) and 26 control subjects (CS; 72·2±7·6 years; 18 women) were included into the study. Plasma adiponectin levels were measured at three time points: within first 24 hours, on Days 2–4, and on Days 5–10 days after the onset of IS. Adiponectin levels were significantly lower in IS patients on admission comparing with CS (medians: 6·0 μg/ml vs. 11·3 μg/ml, respectively; P < 0·05) and continued to decline at later time points (P < 0·001).

Keywords:

• Acute ischemic stroke
• Adiponectin
• Temporal expression
• Plasma
• Human

This study was supported by a grant from the Jagiellonian University Medical College (K/ZDS/000568 to JP).