Management of the neonate at risk for early-onset Group B streptococcal disease (GBS EOD): new paediatric guidelines in Belgium

Abstract

Despite group B streptococcal (GBS) screening in late pregnancy and intrapartum antimicrobial prophylaxis, early-onset sepsis in neonates remains a common source of neonatal morbidity and mortality especially in preterm neonates. The identification of neonates with early-onset sepsis is usually based on perinatal risk factors. Clinical signs are aspecific and laboratory tests are not sensitive. Therefore, many clinicians will overtreat at-risk infants. Inappropriate treatment with antibiotics increases the risk for late-onset sepsis, necrotizing enterocolitis, mortality, and prolongs hospitalisation and costs. In 2003, the Belgian Health Council published guidelines for the prevention of perinatal GBS infections. This report presents the Belgian paediatric management guidelines, which have been endorsed by the Belgian and Flemish societies of neonatology and paediatrics. The most imported changes in the 2014 guidelines are the following: recommendations for a lumbar puncture; clarification of normal spinal fluid parameters and blood neutrophil indices corrected for gestation age; specific timing for diagnostic testing after birth; no indication for diagnostic testing in asymptomatic newborns unless additional risk factors; a revised algorithm for management of neonates according to maternal and neonatal risk factors; and premature infants described as those below 35 weeks instead of 37 weeks. The guidelines were made on the basis of the best evidence and on expert opinion when inadequate evidence exists.

Keywords:

• GBS
• Belgium
• Guideline
• Paediatric
• Management
• Neonate

Acknowledgements

The authors extend their sincere thanks to the other Belgian Health Council GBS working group members [S. Alexander (ULB, Brussels), A. Naessens (UZB, Brussels), C. Potvliege (CHU, Tivoli), G. Claeys (University Hospital Ghent), G. Donders (University Hospitals Leuven), C. Hubinont (Catholic University Louvain-la-Neuve), K. Roelens, (University Hospital Ghent), M. Temmerman (University Hospital Ghent), W. Foulon (University Hospital Brussels), A. Vanholsbeeck (University Hospital Ghent)]. They would also like to thank the chairman of the local scientific paediatric committee (M. Raes) and the presidents of the scientific regional committees of neonatology (G. Naulaers and P. Maton) for their critical revision of the guidelines.