HAEMOLYTIC ANAEMIA CAUSED BY PIPERACILLIN-TAZOBACTAM

I. DapperIntensive Care Unit, AZ Monica, Antwerpen, University Hospital, Leuven, Belgium.Correspondence[email protected]

M. NauwynckIntensive care and emergency department, AZ St-Jan AV, Brugge, University Hospital, Leuven, Belgium.

D. SelleslagHematology, AZ St-Jan, Brugge, University Hospital, Leuven, Belgium.

M. HidajatClinical Biologist, AZ St-Jan, Brugge, University Hospital, Leuven, Belgium.

M. BourgeoisIntensive care and emergency department, AZ St-Jan AV, Brugge, University Hospital, Leuven, Belgium.

P. MartensIntensive care and emergency department, AZ St-Jan AV, Brugge, University Hospital, Leuven, Belgium.

A. WilmerMedical Intensive Care UnitUniversity Hospital, Leuven, Belgium

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Abstract

We report a case of haemolytic anaemia due to the use of piperacillin-tazobactam in a 50-year old woman. Since 2002 4 other cases were reported. Either the presence of piperacillin as tazobactam can induce haemolysis. In all cases discontinuating the drugs resolves the haemolysis. Although drug-induced haemolytic anaemia due to piperacillin-tazobactam is rare, the common use of this antibioticum in the critical care setting should alert the physician as a possible culprit in cases of haemolytic anaemia.

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HAEMOLYTIC ANAEMIA CAUSED BY PIPERACILLIN-TAZOBACTAM

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