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Acta Clinica Belgica
International Journal of Clinical and Laboratory Medicine
Volume 65, 2010 - Issue 6
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Continuing Medical Education

CANCER-RELATED FATIGUE

S. De WaeleDepartment of Medical OncologyUniversity Hospital Ghent, Ghent, BelgiumCorrespondence[email protected]
&
S. Van BelleDepartment of Medical OncologyUniversity Hospital Ghent, Ghent, Belgium
Pages 378-385 | Published online: 30 May 2014
 
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Abstract

Cancer-related fatigue (CRF) is the most commonly reported symptom in patients with cancer with a prevalence up to 100%. It has a signifi cant negative impact on quality of life. An effective management of CRF could signifi cantly reduce the disease burden associated with cancer and its treatment. Unfortunately, the underlying pathophysiology is very complex and not uniform.

This article reviews the possible therapy of contributing factors, nonpharmacological treatment, such as exercise and psychosocial interventions, and pharmacologic approaches in managing CRF. Numerous drugs, such as psychostimulants (methylphenidate, dexamphetamines, modafi nil and pemoline), antidepressants, corticosteroids, L-carnitine, donepezil and guarana have been studied. Methylphenidate, modafi nil and guarana show the most promising results so far. However, additional randomized, placebo-controlled trials are needed to determine the benefi t of these and other drugs in the treatment of CRF.

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