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Abstract
The identification of specific chromosomal abnormalities in the malignant lymphomas has both clinical and biological significance. Translocations t(14;18) and t(8;14) (with variant translocations t(2;8) and t(8;22)) in particular are associated with follicular disease and Burkitt's lymphoma, respectively.
Rearrangements of the immunoglobulin and T cell receptor genes in B and T cell disorders, respectively shown by cytogenetic analysis to be frequently involved in nonrandom translocations, provide useful diagnostic information.
Despite these advances, there is no clear consensus of clinical significance of most chromosome abnormalities because of the heterogenous nature of lymphomas. Further cytogenetic studies are needed of tumors with atypical presentations and patterns of behavior to advance knowledge of lymphoma etiology and to achieve better modes of diagnosis and treatment. (The J Histotechnol 15:253-261, 1992)