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Abstract
Lymphovascular invasion in microinvasive carcinoma of cervix may be an important prognostic indicator. However, a variety of tissue artifacts can make recognition of this invasion difficult in hematoxylin and eosin (H & E) sections. Ulex europaeus agglutinin I lectin (UEA I) used in an immunoperoxidasen technique as an endothelial cell marker facilitates the diagnosis. In this study, 32 cases with suspected vascular involvement were reacted with UEA I on both freshly cut paraffin sections and destained H & E slides. When blocks were available, adjacent sections were also studied with factor VIII antibody. Although there were problems with interpretation in some cases, there was good agreement between what was regarded as vascular space with routine staining and what was revealed with UEA I. Factor VIII was unhelpful. We concluded that UEA I immunohistochemistry is a useful adjunct for assessing capillary-like space involvement in microinvasive carcinoma of cervix. (The J Histotechnol 16:175, 1993)