Comparison of Colloidal Bismuth Subcitrate and Metronidazole, Both in Combination with an H₂-Antagonist as Therapy for Helicobacter pylori

Abstract

In this random study, the efficacy of either colloidal bismuth subcitrate (CBS) or metronidazole in combination with an H₂-antagonist in the treatment of various gastric pathologies was evaluated, along with the trends in antibody levels. Among the 40 Helicobacter pylori-positive patients with various gastroduodenal pathologies who underwent chemotherapy, 27 were treated with CBS and 13 with metronidazole. H. pylori was eradicated in 48.14% of the patients treated with CBS and 53.8% of those treated with metronidazole. After therapy, no statistically significant or slight decrease in the serum levels of antibodies was found.