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Abstract
Over the last 40 years the treatment of colorectal cancer has not achieved the same progress as treatment for other types of tumors. Fluorouracil, with the various modulations, still remains the most effective treatment. This article summarizes the protocols in which fluorouracil is combined with other agents in order to obtain the best results. Researchers in this field need to reach a new consensus on the evaluation of colorectal cancer response to different protocols in order to obtain more precise data on the activity of new anticancer regimens.