Effects of New Quinizarin Derivatives on Both HCV NS5B RNA Polymerase and HIV-1 Reverse Transcriptase Associated Ribonuclease H Activities

Abstract

Human immunodeficiency virus 1 (HIV-1) and Hepatitis C virus (HCV) affect 60 and 170 million infected individuals worldwide, respectively, and co-infection by both pathogens is often observed. This represents a serious public health problem that requires the identification of new drugs targeting essential phases of the life cycle of these two viruses. In this report, the synthesis and inhibitory activity of quinizarin derivatives towards both HCV NS5B polymerase and HIV-1 reverse transcriptase associated functions are reported. Our results demonstrate that anthraquinone derivatives are promising anti-polymerase viral inhibitors.

Keywords:

• HIV-1
• HCV
• RNA-dependent DNA polymerase activity (RDDp)
• Ribonuclease H (RNase H)
• HCV RNA-dependent RNA polymerase (RDRP) NS5B
• quinizarin derivatives