Control of thymocyte proliferation via redox-regulated expression of glycolytic genes

K. Brand Institute of Biochemistry University of Erlangen-Nuremberg, Erlangen , Germany

R. Netzker Institute of Biochemistry University of Erlangen-Nuremberg, Erlangen , Germany

U. Aulwurm Institute of Biochemistry University of Erlangen-Nuremberg, Erlangen , Germany

U. Hermfisse Institute of Biochemistry University of Erlangen-Nuremberg, Erlangen , Germany

D. Fabian Institute of Biochemistry University of Erlangen-Nuremberg, Erlangen , Germany

C. Weigert Institute of Biochemistry University of Erlangen-Nuremberg, Erlangen , Germany

D. Schaefer Institute of Biochemistry University of Erlangen-Nuremberg, Erlangen , Germany

B. Hamm-Kuenzelmann Institute of Biochemistry University of Erlangen-Nuremberg, Erlangen , Germany

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Abstract

Glucose is essential for glycolytic enzyme induction and proliferation of concanavalin A-stimulated rat thymocytes.¹ Resting thymocytes meet their ATP demand mainly by oxidative glucose breakdown (88%), whereas proliferating thymocytes produce 86% by degradation of glucose to lactate and only 14% by oxidation to CO₂ and water despite the presence of oxygen and mitochondria.^1,2 In contrast to non-stimulated resting thymocytes, production of reactive oxygen species (ROS) in the proliferating cells has been shown to be nearly abolished.^2,3

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Control of thymocyte proliferation via redox-regulated expression of glycolytic genes

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Control of thymocyte proliferation via redox-regulated expression of glycolytic genes

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