Abstract
Recent studies of hyperscanning using Magnetic Resonance Imaging (MRI) reported some findings of two-person games involving cooperation and competition. The studies found that certain social indicators, including benign reciprocity, personal agency and trust increased oxygenated blood flow in differentially localized areas (cingulate region) of the brain in both players. The studies raise critical issues pertaining to reality, certainty, ethics, measurement effects and normal brain functioning. They also offer the promise of scientifically based evidence for the nature of person-to-person interactions, including the uncertainties of economic and political decision-making.