Lacidipine in the Treatment of Hypertension in Black African People: Antihypertensive, Biochemical and Haematological Effects

Summary

This is an open trial investigating the efficacy and metabolic effects of 3 months’ treatment with lacidipine in 25 Nigerian Africans with mild to moderate hypertension. There was a significant fall in sitting diastolic blood pressure, with treatment (p = 0.01). There were no significant weight changes. The heart rate initially rose significantly with the drug but this normalised with time. All biochemical and haematological indices remained essentially unchanged during therapy. Lacidipine therefore proved an efficacious and metabolically neutral antihypertensive in mild to moderate hypertension in Africa.

Key words::

• Antihypertensive efficacy
• Lacidipine
• metabolic and haematological effects
• Nigerian Africans