Summary
The intracavernous use of papaverine, phentolamine and prostaglandin E1 (PGE1) is reviewed. The value of treatment combinations is also considered. In particular, the beneficial and harmful effects of long-term intracavernous treatment are considered. For example, the use of PGE1 may be associated with a long-term improvement of the penile microcirculation.
In order to maximise the benefit from intracavernous therapy there is a need for
specialised evaluations, a stepwise management approach and the consideration of
patient preference.