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Current Medical Research and Opinion Volume 17, 2001 - Issue 3
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Research Article

Focus on Clozapine

Miriam Naheed Specialist Registrar, Hollins Park Hospital, Warrington, Cheshire, UK
&
Ben Green Senior Lecturer in Psychiatry, Royal Liverpool University Hospital, Liverpool L69 3GA, UK
Pages 223-229 | Published online: 02 Feb 2009
 
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Summary

Clozapine is a dibenzodiazepine derivative and a truly atypical anti-psychotic. Its therapeutic effects are probably mediated by dopaminergic and serotonergic activity. Although it appears to be the most effective antipsychotic drug for treatment-resistant schizophrenia, its general use is limited because of the risk of agranulocytosis.

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