Preventing postoperative nausea and vomiting: post hoc analysis of pooled data from two randomized active-controlled trials of aprepitant

ABSTRACT

Objective: Compared with the 5HT₃ antagonist ondansetron, the NK₁ antagonist aprepitant has been shown in two double-blind trials to provide greater protection against postoperative vomiting and comparable or greater control of nausea. Post hoc analyses of pooled data from these trials were performed to more fully characterize the efficacy profile of aprepitant in terms of nausea and use of rescue therapy.

Research design and methods: Patients (n = 1599) scheduled for major surgery under general anesthesia (primarily gynecological surgery) were assigned to receive a preoperative dose of aprepitant 40 mg PO, 125 mg PO, or ondansetron 4 mg IV. in two randomized, double-blind, clinical trials.

Main outcome measures: Post-surgery vomiting episodes, use of rescue therapy, and nausea severity (verbal rating scale).

Results: In the 24 hours after surgery, aprepitant 40 mg was more effective than ondansetron for all five endpoints evaluated: (1) no significant nausea (56.4% vs. 48.1%); (2) no nausea (39.6% vs. 33.1%); (3) no vomiting (86.7% vs. 72.4%); (4) no nausea and no vomiting (38.3% vs. 31.4%); and (5) no nausea, no vomiting, and no use of rescue (37.9% vs. 31.2%) ( p < 0.035 for the odds ratio for each comparison). Numerically more patients receiving aprepitant 125 mg also achieved these endpoints compared with ondansetron.

Conclusions: These post hoc analyses confirm the favorable efficacy profile of aprepitant for the prevention of postoperative nausea and vomiting.

Key words: :

• Antiemetic
• Aprepitant
• Emesis
• NK1 antagonist
• Ondansetron
• Postoperative nausea and vomiting

* Presented in part at the annual meetings of the American Society of Anesthesiologists, October 14–18, 2006, Chicago, IL, USA and the American College of Obstetricians and Gynecologists, May 5–9, 2007, San Diego, CA, USA

* Presented in part at the annual meetings of the American Society of Anesthesiologists, October 14–18, 2006, Chicago, IL, USA and the American College of Obstetricians and Gynecologists, May 5–9, 2007, San Diego, CA, USA

Notes

* Presented in part at the annual meetings of the American Society of Anesthesiologists, October 14–18, 2006, Chicago, IL, USA and the American College of Obstetricians and Gynecologists, May 5–9, 2007, San Diego, CA, USA