A new frontier for an old drug? A word of caution for beta-blockers in sepsis!

Abstract

Recent promising findings indicate a possible benefit of β-blockade in septic patients. Ongoing trials on esmolol in septic shock are investigating its hemodynamic effects, focusing on heart rate control and echocardiographic changes, as well as potential anti-inflammatory effects. However, given the complex physiology of sepsis and pharmacological effects on β-blockade, large multi-center trials are essential before such a therapy may be applied safely.

Keywords: :

• Beta blockers
• Esmolol
• Sepsis
• Septic shock

Transparency

Declaration of funding

This editorial was not funded.

Declaration of financial/other relationships

M.O.M. and D.M.M. have disclosed that they have no significant relationships with or financial interests in any commercial companies related to this study or article.

The CMRO peer reviewer on this manuscript has no relevant financial or other relationships to disclose.