![Sample our Bioscience journals, sign in here to start your access, Latest two full volumes FREE to you for 14 days]({"type":"image" , "src" : "/sda/5925/TOC-Subject-Sample-2021-Bioscience.jpg"})
Summary
Amoxycillin is a new penicillin active against gram negative bacteria. Its antibacterial activity is similar to ampicillin and almost 90 % of the strains of Esch. coli and Proteus mirabilis studied were sensitive to 5 μg per ml. Strains of Klebsiella and other Proteus species were highly resistant.
The peak serum level in volunteers after an oral dose of 500 mg. occurred at 2 hours and was 8.4 μg per ml. Urine levels were high and at 2 hours the concentration was nearly 2,000 μg per ml. The average total excretion was 67%.
152 domiciliary patients with urinary tract infections were treated with amoxycillin and the cure rate two weeks after starting treatment was 92% and at six weeks 82 %. The presence of urinary tract abnormalities or a raised serum antibody titre against the infecting organisms significantly increased the failure rate.
Side-effects were similar to other oral penicillins, mainly gastro-intestinal disturbances, vaginitis and skin rashes.
Amoxycillin is a useful addition to the range of oral antibiotics for the treatment of urinary tract infection.