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Summary
Most drugs are used at constant dosage and many are administered together. Under these circumstances, there are many advantages to patients and doctors in providing fixed combinations. Despite some official and academic criticisms, such combinations help patients to adhere to recommended regimens, and overcome the risk of unexpected drug interaction. These advantages must be balanced against the disadvantages of inflexible dosage for some patients but the majority should benefit from the additional simplicity, convenience and safety of combinations, when they need more than one drug at standard dosage.