Penetration of lincomycin (‘Lincocin’) and clindamycin (‘Dalacin’ C) into the synovial cavity in rheumatoid arthritis

Shridhar D. Deodhar The Centre for Rheumatic Diseases and the University Department of Medicine, Royal Infirmary, Glasgow and the Department of Bacteriology, Hawkhead Hospital, Paisley, Scotland

, M.D.,

F. Russell The Centre for Rheumatic Diseases and the University Department of Medicine, Royal Infirmary, Glasgow and the Department of Bacteriology, Hawkhead Hospital, Paisley, Scotland

, M.B., Ch.B., D.Path.,

W. Carson Dick The Centre for Rheumatic Diseases and the University Department of Medicine, Royal Infirmary, Glasgow and the Department of Bacteriology, Hawkhead Hospital, Paisley, Scotland

, M.D., M.R.C.P.,

George Nuki The Centre for Rheumatic Diseases and the University Department of Medicine, Royal Infirmary, Glasgow and the Department of Bacteriology, Hawkhead Hospital, Paisley, Scotland

, M.B., B.S., M.R.C.P., M.R.C.S. &

W. Watson Buchanan The Centre for Rheumatic Diseases and the University Department of Medicine, Royal Infirmary, Glasgow and the Department of Bacteriology, Hawkhead Hospital, Paisley, Scotland

, M.D., F.R.C.P.Ed. and Glas.

Summary

Serum and synovial fluid concentrations of lincomycin and clindamycin were studied in 18 patients with rheumatoid arthritis. The results show that the serum levels exceed synovial fluid levels, and that adequate minimal inhibitory concentrations of both antibiotics were attained within one hour in the synovial fluid.

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Penetration of lincomycin (‘Lincocin’) and clindamycin (‘Dalacin’ C) into the synovial cavity in rheumatoid arthritis

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Penetration of lincomycin (‘Lincocin’) and clindamycin (‘Dalacin’ C) into the synovial cavity in rheumatoid arthritis

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