A clinical assessment of a sustained release preparation of amitriptyline

Summary

The study compares the therapeutic effects of a sustained release form of amitriptyline (‘Lentizol’) with standard amitriptyline in depressed patients using a higher dosage than previously reported. Clinical results were correlated on the Hamilton scale and the Wakefield self-assessment inventory. Similar therapeutic effect was found from the sustained release formulation at two-thirds the dosage of the standard amitriptyline. Side-effects were not significantly different in the two groups; except the sustained release version produced less dryness of the mouth but increased incidence of mild difficulties in micturition.

Key Words::

• Comparative trial
• depression
• amitriptyline
• amitriptyline sustained release