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Current Medical Research and Opinion Volume 1, 1972 - Issue 3
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Research Article

Fenfluramine in corticosteroid-induced obesity

D. C. Cameron Respiratory Diseases Unit, Northern General Hospital, Edinburgh and Department of Respiratory Diseases, University of Edinburgh, Scotland
, M.B., M.R.C.P.,
W. P. U. Kennedy Respiratory Diseases Unit, Northern General Hospital, Edinburgh and Department of Respiratory Diseases, University of Edinburgh, Scotland
, M.B., M.R.C.P.,
Pamela D. Samuel Respiratory Diseases Unit, Northern General Hospital, Edinburgh and Department of Respiratory Diseases, University of Edinburgh, Scotland
, B.Sc.(Nut.) &
G. K. Crompton Respiratory Diseases Unit, Northern General Hospital, Edinburgh and Department of Respiratory Diseases, University of Edinburgh, Scotland
, M.B., M.R.C.P.
Pages 153-158 | Received 21 Nov 1972, Published online: 31 Jul 2008
 
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Summary

A double-blind crossover trial of fenfluramine and placebo tablets, each given for 8 weeks, was conducted on 38 obese asthmatic patients on long-term corticosteroid therapy. The mean weight loss of 2.04 kg. during the period of fenfluramine administration was statistically significant. Side-effects of treatment were on the whole mild, but one patient developed a confusional state associated with gross cerebral dysrhythmia.

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