A controlled double-blind comparison of lorazepam and diazepam in anxiety neurosis

Summary

A controlled double-blind trial of lorazepam and diazepam was carried out in 43 ou patients suffering from anxiety neurosis. The dose of lorazepam was 2 to 6 mg. a da and that of diazepam 10 to 30 mg. a day, the duration of treatment being 4 week. On the basis of mean score reduction on Hamilton's scale and overall response, n significant difference was revealed between the anxiolytic actions of the drugs. With regard to central nervous side-effects, however, there was a suggestion that lorazepai may be less prone to cause them than diazepam.

Key words: :

• Neuroses
• anxiety
• tranquillizing agents
• drug therapy