Further evaluation of phentolamine (‘Regitine’) in cardiac arrhythmias

Summary

Phentolamine (‘Regitine' Ciba), an alpha adrenergic blockade drug, was used in an acute study in various types of cardiac arrhythmias to evaluate its antiarrhythmic property. The drug was used in a dose of 0.5 mg. per min. 1.V.for 20 min. The drug was found to be of benefit in treating VPCs, VT and second degree heart block particularly associated with congestive heart failure. Supraventricular arrhythmias responded less favourably. No side-effects were recordedduring its clinicaluse. Phentolamine is a useful addition to the existing antiarrhythmic drugs.

Key words: :

• Phentolamine
• arrhythmia
• electrocardiography