Effect of combined administration of clofibrate and neomycin on serum cholesterol levels in familial type II hyperlipoproteinaemia

Summary

Eight patients suffering from familial Type II hyperlipoproteinaemia were treated with clofibrate for a period of 12 weeks and this was followed by combined therapy with clofibrate and neomycin for a further period of 12 weeks. It was found that neomycin, though free from major side-effects, failed to augment the hypocholesterolaemic action of clofibrate.

Key words: :

• Hyperlipaemia
• essential familial
• clofibrate
• neomycin