Doxycycline levels in prostatic tissue and blood

Summary

Doxycycline was administered orally to 23 patients scheduled for prostatectomy or radical cystectomy. Blood and prostatic tissue samples were collected simultaneously during the operation and subsequently assayed for doxycycline levels. The concentration of doxycycline in the prostatic tissue was on average 2.75 mcg./g., which is far above the therapeutic level. The lowest level recorded was 0.85 mcg./g. and the highest level recorded was 4.81 mcg./g.

The findings suggest that there is a tendency for this antibiotic to accumulate in the prostatic tissue. This is in good agreement with the clinical observations of the excellent effect of doxycycline treatment in patients with chronic bacterial prostatitis.