Section 1 A Comparative Study of Ibuprofen (‘Brufen’) And Indomethacin in Uncomplicated Arthrosis

Summary

A double-blind crossover comparison of 1200 mg. ibuprofen daily and 75 mg. indomethacin daily was carried out over an 8-week period in 39 patients with uncomplicated osteoarthrosis. The results from objective assessments of joint measurement were similar for both drugs. Only 16 patients noted any difference between the two treatment periods, and preferences, as assessed by physician and patients, were about equally in favour of each drug. There was, however, a marked order effect with preference for the second 4-week treatment period. Fewer patients reported side-effects when receiving ibuprofen.

Key Words::

• Ibuprofen
• anti-inflammatory agents
• indomethacin
• osteoarthritis