Long-term clinical study of glipizide

Summary

Twenty-eight patients with maturity onset diabetes were treated with glipizide and studied for periods up to 30 months. Dosage ranged from 5 to 40 mg. daily, most patients requiring 20 mg. daily for satisfactory control: 40% also required biguanide. The poorest response to treatment was in those patients who had failed to respond to other sulohonylureas.

Biological tolerance of glipizide was good, except in 2 patients who had raised alkaline phosphatase levels. There were no significant changes in serum cholesterol, plasma triglycerides, or lipoprotein electrophoretic measurements.

Key Words::

• Glipizide
• antidiabetics
• diabetes mellitus