A single-blind comparative study of once daily dothiepin (‘Prothiaden’) and divided daily doses of amitriptyline

Summary

Forty-eight patients took part in a single-blind clinical trial comparing a once daily dose of dothiepin (75 mg)and 25 mg 3-times a day of amitriptyline. The results showed that dothiepin caused a greater improvement than amitriptyline after 4 weeks of treatment as judged by depression scores, total scores and global assessments. The incidence of side-effects was less with dothiepin and in those patients who actually reported side-effects the severity was much less with dothiepin than with amitriptyline.

Key Words::

• Dothiepin
• amitriptyline
• antidepressive agents
• depression