The effect of anti-inflammatory and antirheumatic drugs on inflammation in the rat

Summary

The anti-inflammatory effects of flurbiprofen and a number of other antirheumatic agents were studied in the rat using a model of inflammation, which involved the subcutaneous implantation of polyurethane cubes impregnated with an irritant. Results of acute and chronic studies indicated that flurbiprofen was extremely effective in suppressing both fluid and cellular phases of inflammation and, in this model, was comparable in potency to prednisolone.

Key Words::

• Flurbiprofen
• anti-inflammatory agents
• disease models
• animal