Diuretic action of Bay g 2821 in oedema-free volunteers

Summary

The sulphonamide-free diuretic Bay g 2821 was tested under standardized conditions on 43 oedema-free volunteers. The threshold dose was 10 mg (0.14 mg/kg). The dose-response curve was practically linear for doses up to 80 mg. The excretion of sodium and chloride was very high, and that of potassium, magnesium and calcium markedly lower. Intrarenal haemodynamic investigations showed that the inulin clearance was unchanged, and the PAH clearance increased slightly. The tubular reabsorption of sodium and chloride was inhibited. Side-effects after a single oral dose did not occur.

Key Words::

• Bay g 2821
• Diuretics
• dose-response relationship
• drug