The mode of action of theophylline

Summary

The different pharmacological actions of theophylline are reviewed. Apart from its bronchodilating effect, theophylline acts on the respiratory centre and has valuable cardiovascular and renal effects. Side-effects are gastro-intestinal intolerance, central nervous stimulation and cardiovascular disturbances. The main hypotheses concerning the molecular basis of theophylline's activity are discussed. Although phosphodiesterase inhibition has been generally accepted, until recently, as the mechanism probably involved in the bronchodilating activity, other mechanisms such as inhibition of beta-adrenoceptor subsensitivity, inhibition of the adenosine receptor and intracellular translocation of calcium may also be involved and more relevant to the anti-allergic activity.

Key Words::

• Theophylline
• pharmacology
• pharmacodynamics