The treatment of 'cimetidine resistant peptic ulcers by ranitidine hydrochloride: A new histamine H₂-receptor antagonist

Summary

Twelve patients with endoscopically confirmed peptic ulcers which had failed to heal despite standard cimetidine therapy were treated with 300 mg ranitidine hydrochloride daily for 4 to 8 weeks. Nine patients had complete symptomatic relief although the ulcer was found to have healed endoscopically in only six. Two patients derived no benefit from treatment and in 1 patient symptoms continued despite ulcer healing. Ranitidine would appear, therefore, to be of benefit in some ‘cimetidine resistant’ patients.

Key Words::

• Ranitidine
• cimetidine
• peptic ulceration