Comparison of the antimicrobial activity and beta-lactamase resistance of cef otiam (CGP/14221 E) with that of cefotaxime, cefuroxime, cefoxitin and cephalothin

J. Tselentis Department of Pathologic Physiology, School of Medicine, National University of Athens, Athens, Greece

Th. Cordossis Department of Pathologic Physiology, School of Medicine, National University of Athens, Athens, Greece

S. Grammenou Department of Pathologic Physiology, School of Medicine, National University of Athens, Athens, Greece

G. Eliopoulos Department of Pathologic Physiology, School of Medicine, National University of Athens, Athens, Greece

V. Kyritsis Department of Pathologic Physiology, School of Medicine, National University of Athens, Athens, Greece

Summary

A study was carried out to compare the minimum inhibitory concentrations of cefotiam, cefotaxime, cefuroxime, cefoxitin and cephalothin against 355 strains of Gram-negative bacteria including Pseudomonas aeruginosa. Cefotiam was shown to be more active than cefuroxime, cefoxitin and cephalothin and equal to or slightly less active than cefotaxime. Study of the minimum bactericidal concentrations of cefotiam showed that the time required for eradication of the micro-organisms was rapid. It was found that cefotiam, cefotaxime, cefuroxime and cefoxitin were resistant to the hydrolysis caused by the constitutive beta-lactamases studied.

Key Words::

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Order Reprints Request Corporate Permissions

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

Request Academic Permissions

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.

Comparison of the antimicrobial activity and beta-lactamase resistance of cef otiam (CGP/14221 E) with that of cefotaxime, cefuroxime, cefoxitin and cephalothin

Information for

Open access

Opportunities

Help and information

Comparison of the antimicrobial activity and beta-lactamase resistance of cef otiam (CGP/14221 E) with that of cefotaxime, cefuroxime, cefoxitin and cephalothin

Summary

Reprints and Corporate Permissions

Academic Permissions

Related research

To cite this article:

Download citation

Information for

Open access

Opportunities

Help and information

Keep up to date

Your download is now in progress and you may close this window

Login or register to access this feature