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Summary
The effects of proglumide on the variations in serum gastrin concentrations and of gastric secretion after calcium gluconate intravenous infusion were investigated in 5 patients with gastric and 5 with duodenal ulcers. Gastrin concentration exhibited a major peak after 15 minutes, and a minor one 90 minutes after calcium gluconate administration. After proglumide dosing (400 mg by bolus i. v. injection just before calcium administration), the initial peak tended to be inhibited (p<0.1), and the second was significantly inhibited (p<0.05). Gastric acid output significantly increased after calcium gluconate, with a peak in the 30 to 60 minute fraction. Proglumide markedly inhibited the increase to a significant extent (p<0.05) in the peak fraction. Gastric juice volume also increased after calcium gluconate, with a peak in the 30 to 60 minute fraction. Proglumide had little, if any, effect on this parameter. Apart from its already known gastrin-receptor antagonism, proglumide appears, therefore, to inhibit gastric secretion also through an inhibition of gastrin release from antral G-cells.