Abstract
Background. The Spirit of E.A.G.L.E.S. is a National Cancer Institute funded Special Populations Network. Prior to its inception, there was limited infrastructure available to American Indian and Alaska Native populations to support cancer control activities. Methods. Awareness has been raised about the burden of cancer in this special population. Results and Conclusions. Changes have started to support truly comprehensive cancer control across the cancer care continuum and will drive future community-based, participatory action research.