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Original Articles

Molecular Size of Collagen Peptide Reverses the Permeability of Caco-2 Cells

, , , , , & show all
Pages 1123-1125 | Received 07 Jan 2010, Accepted 02 Feb 2010, Published online: 22 May 2014
 

Abstract

Intestinal permeability to size-classified fish collagen peptides (FCPs) was examined using Caco-2 monolayers. Minimum-sized FCPs were most efficiently transported across the Caco-2 monolayers. Permeability depended on peptide size. It was independent of the H+-coupled peptide transport system but was associated with tight junction permeability, suggesting that the paracellular pathway is responsible for transepithelial transport of collagen peptides.

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