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Original Articles

Melanin Biosynthesis Inhibitors from Tarragon Artemisia dracunculus

, , , , , , , , & show all
Pages 1628-1630 | Received 15 Apr 2011, Accepted 13 May 2011, Published online: 22 May 2014
 

Abstract

The EtOH extract of tarragon Artemisia dracunculus, a perennial herb in the family Asteraceae, was found to potently inhibit α-melanocyte-stimulating hormone (α-MSH) induced melanin production in B16 mouse melanoma cells. Bioassay-guided fractionation led to the isolation of two alkamide compounds, isobutyl (1) and piperidiyl (2) amides of undeca-2E,4E-dien-8,10-dynoic acid. The respective EC50 values for melanin biosynthesis inhibition were 1.8 and 2.3 μg/mL for 1 and 2.

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