Effects of Daintain/AIF-1 on β Cell Dysfunction in INS-1 Cells

Xinyuan HUANGKey Laboratory of Molecular Biophysics of the Ministry of Education, College of Life Science and Technology, Huazhong University of Science and Technology

Yanying ZHAOSchool of Life Science and Technology, Southwest University for Nationalities

Shaohui JIAKey Laboratory of Molecular Biophysics of the Ministry of Education, College of Life Science and Technology, Huazhong University of Science and Technology

Dongjing YANKey Laboratory of Molecular Biophysics of the Ministry of Education, College of Life Science and Technology, Huazhong University of Science and Technology

Zhengwang CHENKey Laboratory of Molecular Biophysics of the Ministry of Education, College of Life Science and Technology, Huazhong University of Science and Technology

Abstract

We investigated the effects of daintain/AIF-1, a novel inflammatory cytokine, on INS-1β cells. Cells incubated with daintain/AIF-1 showed decreased cell viability and glucose-stimulated insulin secretion, as well as upregulated apoptosis and NO production. These deleterious effects of daintain/AIF-1 indicate that daintain/AIF-1 plays important roles in the dysfunction of pancreatic β cells in type-1 diabetes.

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Effects of Daintain/AIF-1 on β Cell Dysfunction in INS-1 Cells

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Effects of Daintain/AIF-1 on β Cell Dysfunction in INS-1 Cells

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