Hyuganatsu Orange (Citrus tamurana Hort. Ex Tanaka) Contains a Water Soluble Substance That Suppresses Bone Loss in Ovariectomized Rats

Masatoshi YAMAGUCHIDepartment of Obstetrics and Gynecology, Faculty of Medicine, University of Miyazaki

Hiroshi SAMESHIMADepartment of Obstetrics and Gynecology, Faculty of Medicine, University of Miyazaki

Tsuyomu IKENOUEDepartment of Obstetrics and Gynecology, Faculty of Medicine, University of Miyazaki

Makoto TSUBOIIchimaru Phalcos Co., Ltd.

Muneaki HIDAKADepartment of Pharmacy, Faculty of Medicine, University of Miyazaki

Kazuhiko ARIMORIDepartment of Pharmacy, Faculty of Medicine, University of Miyazaki

Abstract

We investigated whether Hyuganatsu orange (Citrus tamurana Hort. ex Tanaka) contains water and acetic-acid soluble substances that increase bone mineral density (BMD) in ovariectomized rats. In in vivo study, femoral BMD can significantly increased. In in vitro study, tartrate-resistant acid phosphatase (TRAP) positive cells significantly decreased. We speculate that Hyuganatsu orange contains biologically active substances other than hesperidin that increase BMD.

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Hyuganatsu Orange (Citrus tamurana Hort. Ex Tanaka) Contains a Water Soluble Substance That Suppresses Bone Loss in Ovariectomized Rats

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Hyuganatsu Orange (Citrus tamurana Hort. Ex Tanaka) Contains a Water Soluble Substance That Suppresses Bone Loss in Ovariectomized Rats

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