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Bioscience, Biotechnology, and Biochemistry Volume 76, 2012 - Issue 4
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Original Articles

Reduction of Overall Helicobacter pylori Colonization Levels in the Stomach of Mongolian Gerbil by Lactobacillus johnsonii La1 (LC1) and Its in Vitro Activities against H. pylori Motility and Adherence

Hirokazu ISOBEDivision of Bacteriology, Department of Infectious Disease Control and International Medicine, Niigata University Graduate School of Medical and Dental Sciences
,
Akihito NISHIYAMADivision of Bacteriology, Department of Infectious Disease Control and International Medicine, Niigata University Graduate School of Medical and Dental Sciences
,
Tomomi TAKANODivision of Bacteriology, Department of Infectious Disease Control and International Medicine, Niigata University Graduate School of Medical and Dental Sciences
,
Wataru HIGUCHIDivision of Bacteriology, Department of Infectious Disease Control and International Medicine, Niigata University Graduate School of Medical and Dental Sciences
,
Saori NAKAGAWADivision of Bacteriology, Department of Infectious Disease Control and International Medicine, Niigata University Graduate School of Medical and Dental Sciences
,
Ikue TANEIKEDivision of Bacteriology, Department of Infectious Disease Control and International Medicine, Niigata University Graduate School of Medical and Dental Sciences
,
Yoichi FUKUSHIMANestlé Japan, Ltd., Nutrition Business Group
&
Tatsuo YAMAMOTODivision of Bacteriology, Department of Infectious Disease Control and International Medicine, Niigata University Graduate School of Medical and Dental Sciences
 show all
Pages 850-852 | Received 01 Dec 2011, Accepted 15 Jan 2012, Published online: 22 May 2014
 
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Abstract

The effects of Lactobacillus johnsonii La1 (LC1) on Helicobacter pylori colonization in the stomach were investigated. H. pylori colonization and gastritis in LC1-inoculated Mongolian gerbils were significantly less intense than those in the control animals. LC1 culture supernatant (>10-kDa fraction) inhibited H. pylori motility and induced bacterial aggregation in human gastric epithelial cells, suggesting the potential of clinical use of LC1 product.

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Related Research Data

Systematic review: are probiotics useful in controlling gastric colonization by Helicobacter pylori?
Source: Wiley
GroEL of Lactobacillus johnsonii La1 (NCC 533) is cell surface associated: potential role in interactions with the host and the gastric pathogen Helicobacter pylori.
Source: American Society for Microbiology
Helicobacter pylori treatment in the era of increasing antibiotic resistance
Source: BMJ
Efficacy of Lactobacillus-supplemented triple therapy for H. pylori eradication: A meta-analysis of randomized controlled trials.
Source: Public Library of Science (PLoS)
Lipoteichoic acids from Lactobacillus johnsonii strain La1 and Lactobacillus acidophilus strain La10 antagonize the responsiveness of human intestinal epithelial HT29 cells to lipopolysaccharide and gram-negative bacteria.
Source: American Society for Microbiology
Suppressive effect of frequent ingestion of Lactobacillus johnsonii La1 on Helicobacter pylori colonization in asymptomatic volunteers
Source: Oxford University Press (OUP)
Novel Insights of Lymphomagenesis of Helicobacter pylori-Dependent Gastric Mucosa-Associated Lymphoid Tissue Lymphoma
Source: MDPI AG
A novel probiotic, Lactobacillus johnsonii 456, resists acid and can persist in the human gut beyond the initial ingestion period
Source: Taylor & Francis Group
L. JOHNSONII FERMENTED MILK AND H. PYLORI GASTRITIS
Source: Wiley

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