Isolation of 9-Hydroxy-10E,12Z-octadecadienoic Acid, an Inhibitor of Fat Accumulation from Valeriana fauriei

Keiji YUKIDepartment of Biosciences and Informatics, Keio University

Mariko IKEDADepartment of Biosciences and Informatics, Keio University

Kenji MIYAMOTODepartment of Biosciences and Informatics, Keio University

Osamu OHNODepartment of Chemistry, Keio University

Kaoru YAMADADepartment of Chemistry, Kanagawa University

Daisuke UEMURADepartment of Chemistry, Kanagawa University

Abstract

An EtOH extract of Valeriana fauriei was found to exhibit potent inhibition of fat accumulation against 3T3-L1 murine adipocytes. After performing several chromatographic steps, we successfully isolated the conjugated linoleic acid derivative, 9-hydroxy-10E,12Z-octadecadienoic acid (9-HODE). Synthesized 9-HODE and its analogs showed inhibitory activity against fat accumulation.

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Isolation of 9-Hydroxy-10E,12Z-octadecadienoic Acid, an Inhibitor of Fat Accumulation from Valeriana fauriei

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Isolation of 9-Hydroxy-10E,12Z-octadecadienoic Acid, an Inhibitor of Fat Accumulation from Valeriana fauriei

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