Induction of Apoptosis in MCF-7 Cells by β-1,3-Xylooligosaccharides Prepared from Caulerpa lentillifera

Abstract

β-1,3-Xylan was prepared from the green alga, Caulerpa lentillifera, and hydrolyzed to oligosaccharides by a mild acid treatment. The average degree of polymerization was about 5. The oligosaccharides reduced the number of viable human breast cancer MCF-7 cells in a dose-dependent manner, and induced chromatin condensation and degradation of poly ADP-ribose polymerase, indicating that they induced apoptosis in MCF-7 cells.

• Caulerpa lentillifera
• β-1,3-xylooligosaccharide
• apoptosis
• MCF-7 human breast cancer cell