Identification and Biological Activities of Bryostatins from Japanese Bryozoan

Sayo UENODepartment of Food Science and Biotechnology, Graduate School of Agriculture, Kyoto University

Ryo C. YANAGITADepartment of Applied Biological Science, Faculty of Agriculture, Kagawa University

Kazuma MURAKAMIDepartment of Food Science and Biotechnology, Graduate School of Agriculture, Kyoto University

Akira MURAKAMIDepartment of Food Science and Biotechnology, Graduate School of Agriculture, Kyoto University

Harukuni TOKUDADepartment of Complementary and Alternative Medicine Clinical R&D, Graduate School of Medical Science, Kanazawa University

Nobutaka SUZUKIDepartment of Complementary and Alternative Medicine Clinical R&D, Graduate School of Medical Science, Kanazawa University

Takeshi FUJIWARAOP-BIO Factory Co., Ltd.

Kazuhiro IRIEDepartment of Food Science and Biotechnology, Graduate School of Agriculture, Kyoto University

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Abstract

Six bryostatins were isolated from Japanese bryozoan by evaluating their binding to the C1B domain of protein kinase Cδ (PKCδ). Structure-activity studies of bryostatins 4, 10, and 14 suggested that the ester group at C20 was not necessary for binding to and activating PKCδ. These bryostatins showed significant anti-tumor-promoting activity in induction tests with the Epstein-Barr virus early antigen.

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Identification and Biological Activities of Bryostatins from Japanese Bryozoan

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Identification and Biological Activities of Bryostatins from Japanese Bryozoan

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