Two Distinct Epitopes on the Ovalbumin 323-339 Peptide Differentiating CD4⁺T Cells into the Th2 or Th1 Phenotype

Haruyo NAKAJIMA-ADACHIResearch Center for Food Safety, Graduate School of Agricultural and Life Sciences, The University of Tokyo;Department of Applied Biological Chemistry, Graduate School of Agricultural and Life Science, The University of Tokyo

Emiko KOIKEDepartment of Applied Biological Chemistry, Graduate School of Agricultural and Life Science, The University of Tokyo

Mamoru TOTSUKADepartment of Applied Biological Chemistry, Graduate School of Agricultural and Life Science, The University of Tokyo

Erika HIRAIDEResearch Center for Food Safety, Graduate School of Agricultural and Life Sciences, The University of Tokyo;Department of Applied Biological Chemistry, Graduate School of Agricultural and Life Science, The University of Tokyo

Yoshio WAKATSUKIDepartment of Clinical Bio-regulatory Science, Kyoto University Graduate School of Medicine

Hiroshi KIYONODepartment of Mucosal Immunology, Institute of Medical Science, The University of Tokyo

Satoshi HACHIMURAResearch Center for Food Safety, Graduate School of Agricultural and Life Sciences, The University of Tokyo;Department of Applied Biological Chemistry, Graduate School of Agricultural and Life Science, The University of Tokyo

show all

Click to increase image sizeClick to decrease image size

The epitopes for OVA323-339-specific CD4⁺T cells from OVA23-3 food allergy model and DO11.10 tolerant induction model mice were analyzed. We found that OVA23-3 CD4⁺T cells recognized the N-terminal region, showing strong proliferation and the Th2-phenotype, and that DO11.10 CD4⁺T cells recognized the C-terminal region, showing milder proliferation and a Th1-skewed response. These differences may regulate the responses of those mice to OVA-feeding, inflammation and tolerance.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Order Reprints Request Corporate Permissions

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

Request Academic Permissions

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.

Two Distinct Epitopes on the Ovalbumin 323-339 Peptide Differentiating CD4⁺T Cells into the Th2 or Th1 Phenotype

Information for

Open access

Opportunities

Help and information

Two Distinct Epitopes on the Ovalbumin 323-339 Peptide Differentiating CD4+T Cells into the Th2 or Th1 Phenotype

Reprints and Corporate Permissions

Academic Permissions

Related research

To cite this article:

Download citation

Information for

Open access

Opportunities

Help and information

Keep up to date

Your download is now in progress and you may close this window

Login or register to access this feature

Two Distinct Epitopes on the Ovalbumin 323-339 Peptide Differentiating CD4⁺T Cells into the Th2 or Th1 Phenotype