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Original Articles

Changes in NAD Content Induced by Nicotinic Acid-Related Compounds in K562 Cells during Differentiation

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Pages 1583-1585 | Received 20 Feb 2013, Accepted 11 Apr 2013, Published online: 22 May 2014
 

Abstract

Two nicotinic acid-related compounds were found to induce erythroid differentiation in K562 cells. We investigated the changes in nicotinamide adenine dinucleotide (NAD) content induced by nicotinic acid-related compounds during differentiation. The NAD content was reduced by a treatment with nicotinic acid and isonicotinic acid. These results provide important clues toward elucidating the erythroid differentiation mechanism.

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