Bone Resorption Inhibitors from Hop Extract

Hiroyasu TobePharma Research and Development Division, Drug Discovery Research Laboratories, Hoechst Japan Limited, 3–2 Minamidai 1-chome, Kawagoe-shi, Saitama 350–11, Japan

Yoshifumi MurakiPharma Research and Development Division, Drug Discovery Research Laboratories, Hoechst Japan Limited, 3–2 Minamidai 1-chome, Kawagoe-shi, Saitama 350–11, Japan

Kazuyuki KitamuraPharma Research and Development Division, Drug Discovery Research Laboratories, Hoechst Japan Limited, 3–2 Minamidai 1-chome, Kawagoe-shi, Saitama 350–11, Japan

Osamu KomiyamaPharma Research and Development Division, Drug Discovery Research Laboratories, Hoechst Japan Limited, 3–2 Minamidai 1-chome, Kawagoe-shi, Saitama 350–11, Japan

Yusuke SatoPharma Research and Development Division, Drug Discovery Research Laboratories, Hoechst Japan Limited, 3–2 Minamidai 1-chome, Kawagoe-shi, Saitama 350–11, Japan

Tatsuo SugiokaPharma Research and Development Division, Drug Discovery Research Laboratories, Hoechst Japan Limited, 3–2 Minamidai 1-chome, Kawagoe-shi, Saitama 350–11, Japan

Hiromi B. MaruyamaPharma Research and Development Division, Drug Discovery Research Laboratories, Hoechst Japan Limited, 3–2 Minamidai 1-chome, Kawagoe-shi, Saitama 350–11, Japan

Eriko MatsudaPharma Research and Development Division, Drug Discovery Research Laboratories, Hoechst Japan Limited, 3–2 Minamidai 1-chome, Kawagoe-shi, Saitama 350–11, Japan;Hoshi University, Faculty of Pharmaceutical Sciences, 4–41 Ebara 2-chome, Shinagawa-ku, Tokyo142, Japan

Masahiro NagaiPharma Research and Development Division, Drug Discovery Research Laboratories, Hoechst Japan Limited, 3–2 Minamidai 1-chome, Kawagoe-shi, Saitama 350–11, Japan;Hoshi University, Faculty of Pharmaceutical Sciences, 4–41 Ebara 2-chome, Shinagawa-ku, Tokyo142, Japan

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Abstract

We searched hop extract for active component(s) that inhibited bone resorption in the pit formation assay, and isolated xanthohumol and humulone as active ingredients. Especially humulone had extraordinarily strong inhibitory activity and the IC₅₀ (concentration of 50% inhibition) value was 5.9 × 10 ⁻⁹ m.

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Bone Resorption Inhibitors from Hop Extract

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Bone Resorption Inhibitors from Hop Extract

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