Facile Syntheses of AM-toxins and Analogs as Cyclic Depsipeptides by the Solid-phase Method

Abstract

The cyclic depsipeptides, AM-toxins I and II and AM-toxin I analogs, were efficiently and rapidly prepared by the Fmoc-based solid-phase method for the synthesis of linear depsipeptides, with N-[(dimethylamino)-1H-1,2,3-triazolo[4,5-b]pyridin-1-ylmethylene]-N-methylmethanaminium hexafluorophosphate N-oxide (HATU) being used for their subsequent cyclization.

• AM-toxin
• host-specific toxin
• cyclic depsipeptide
• solid-phase synthesis
• HATU