Simple Synthesis of Both Enantiomers of the C7-C12 Segment of Epothilones: Bioscience, Biotechnology, and Biochemistry: Vol 62, No 12

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Abstract

Both enantiomers of the C7-C12 segment (3 and 4) of antitumor antibiotics epothilones (1and 2) were synthesized from methyl (R)- and (S)-3-hydroxy-2-methylpropionate (5 and 6) in five steps in a fair yield.

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Simple Synthesis of Both Enantiomers of the C7-C12 Segment of Epothilones

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Simple Synthesis of Both Enantiomers of the C7-C12 Segment of Epothilones

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