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Original Articles

Chemistry of Zerumbone. 2. Regulation of Ring Bond Cleavage and Unique Antibacterial Activities of Zerumbone Derivatives

, , , , , , & show all
Pages 2193-2199 | Received 13 Mar 2001, Accepted 11 May 2001, Published online: 22 May 2014
 

Abstract

Further investigation of the chemistry of the elevenmembered cyclic sesquiterpene, zerumbone, the major component of the wild ginger, Zingiber zerumbet Smith, has revealed a new selective epoxidation process, a further example of a novel Favorskii-initiated double ring contraction, and a regiospecific fragmentation of zerumbone dibromide derivatives. Several zerumbone derivatives were found to be selective inhibitors of the growth of Gram-positive bacteria.

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